RNA modulation by RNA-targeting Cas proteins

My lab has a long-standing interest in understanding the roles that proteins play in controlling RNA processing, from alternative splicing, polyadenylation, RNA editing, and translation control. Recently, we have developed methods to manipulate RNA processing events as well. I will discuss our efforts in repurposing CRISPR/Cas proteins for modulating RNA processing.


Gene Yeo, Ph.D. MBA is a Full Professor of Cellular and Molecular Medicine at the University of California, San Diego (UCSD) and a visiting Professor at the National University of Singapore. Dr. Yeo has a BSc in Chemical Engineering and a BA in Economics from the University of Illinois, Urbana-Champaign, a Ph.D. in Computational Neuroscience from Massachusetts Institute of Technology and an MBA from the UCSD Rady School of Management. In 2005, Dr. Yeo was appointed the inaugural Junior Fellow at the Crick-Jacobs Center for Theoretical and Computational Biology at the Salk Institute and joined UCSD as an Assistant Professor in 2008, achieving tenure in 2014. Dr. Yeo’s research interest is in understanding and manipulating RNA processing in developmental and disease models. Dr. Yeo is a recipient of Alfred P Sloan Fellowship in recognition of his work in computational molecular biology (2011) and the inaugural Early Career Award from the International RNA Society (2017).