About the 2018 Bridging Biomedical Worlds Conference

As international collaborations in new and exciting research fields are forged between East and West, it seemed fitting for Fondation IPSEN and the American Association for the Advancement of Science to launch this new “Bridging Biomedical Worlds” conferences series. With these annual international conferences, to be held in different countries in Asia, we hope not only to facilitate the exchange of knowledge about important advances in key research areas but also to boost communication and cooperation among researchers, clinicians, and industry scientists from East and West. The discovery of CRISPR/Cas, a natural immune defense system in bacteria, has revolutionized genome editing enabling precise and highly efficient cutting and splicing of genomes from across the animal and plant kingdoms. The power and potential of CRISPR/Cas and other genome editing tools for both studying basic biological processes and for understanding and treating a broad swath of diseases is the theme of our 2018 Bridging Biomedical Worlds conference. This conference, entitled “Genome Editing: The Next Frontier”, will be held in Singapore, February 4-7, 2018, and is jointly organized by Fondation IPSEN, AAAS/Science and AAAS/Science Translational Medicine, and the Institute of Molecular and Cell Biology A*STAR Singapore. The meeting will cover a broad range of topics including natural bacterial immune mechanisms, the next generation of genome editing tools, applications of genome editing tools in scientific discovery, and therapeutic applications of genome editing.

18 lectures

10 poster presentations

180 attendees

logo program Scientific Program

This year, the scientific program is composed of 2 keynote lectures, 14 lectures and 2 short talks that are arranged in 4 sessions. Finally, 1 panel discussions will allow speakers to discuss the scientific and translational challenges of genome editing.

  • 1.45 – 2.00 pm

    Welcome & Opening Remarks
    James. A LEVINE (Fondation IPSEN)
    Orla M. SMITH (AAAS/ Science Translational Medicine)
    Vinay TERGAONKAR (Institute of Molecular and Cell Biology, A*STAR)

  • 2.00 – 3.00 pm

    Opening Keynote Lecture
    Engineering smarter T cells, Carl H. JUNE

  • 3.30 – 4.30 pm

    Session I: CRISPRs for Attack and Defense
    Adaptation mechanisms in CRISPR-Cas immunity, Dipali SASHITAL
    Beyond CRISPR: anti-phage defense in the wild, Rotem SOREK

  • 4.30 – 4.45 pm

    Short talk (selected from posters)
    Therapeutic genome editing for Charcot-Marie-Tooth 1A, Seokjoong KIM 

  • 9.30 am – 12.00 pm

    Session II: Advances in Genome Editing
    Base Editing: Genome Editing Without Double-Stranded DNA Cleavage, Nicole GAUDELLI
    Structures, mechanisms and engineering of CRISPR-Cas genome editors, Martin JINEK
    Genome Engineering Technologies for Programming and Recoding Organisms, Farren ISAACS
    RNA modulation by RNA-targeting Cas proteins, Gene YEO

  • 12.00 – 12.15 pm

    Short talk (selected from posters)
    In vivo CRISPR screening to identify new immune checkpoint regulators, Fabrice VANDEPUT

  • 1.45 – 3.15 pm

    Session III: CRISPRs as a Discovery Tool
    CRISPR/Cas9 mediated genome editing in mice and its application for the study of reproduction, Mashito IKAWA
    New frontiers in functional genomics using high-throughput genome engineering, Neville SANJANA
    CRISPR tools to study and fight pathogenic bacteria, David BIKARD

  • 3.45 – 4.45 pm

    Session IV: Panel discussion: Scientific and Translational Challenges for Genome Editing
    Eric N. OLSON
    Paula CANNON, Andrea CRISANTI, Farren ISAACS, Waseem QASIM & Neville SANJANA

  • 9.00 am – 12.00 pm

    Session V: Therapeutic Applications of Gene Editing
    Gene Editing for Primary Immunodeficiencies, Suk See DE RAVIN
    Optimizing homology-directed repair of DNA breaks in hematopoietic stem cells, Paula CANNON
    Correction of Duchenne Muscular Dystrophy by Genome Editing, Eric OLSON
    Gene edited T cell therapies for leukaemia, Waseem QASIM
    Editing population genetics for vector control, Andrea CRISANTI

  • 12:00 – 1:00 pm

    Closing Keynote Lecture
    Functional Genomics to Study Cancer, David SABATINI

  • 1.00 – 1.15 pm

    Closing remarks
    Wanjin HONG (Institute of Molecular and Cell Biology, A*STAR)
    Valda VINSON (AAAS/ Science, Washington DC, USA)

video 2016 Bridging Biomedical Worlds Conference

Bridging Biomedical Worlds 2016, held in Hong Kong, brought together an international roster of top scientists working at the interface of the microbiota and the host. Some speakers from that meeting have agreed to share their work with us. A series of short videos present their insights into the implications of the gut microbiota in major disorders, such as, obesity, allergy and cancer.